Ovarian cancer |
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| 2007-12-23 | No history |  | Add My version | |
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| Mind map Ovarian cancer (from MedMaps.co.uk) - the online mind map resource for medical students and doctors. Gynaecology. Medicine. | |
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OVARIAN CANCER
INCIDENCE
AGE
Increases with advancing age
mean age 58
usually btwn 5th and 8th decade
GEOGRAPHY
developed >developing
5tth commonest ca in UK females
PREDISPOSING FACTORS
Family Hx
BRCA1 carrier= 40-60% risk
BRCA2 carrier= 20-30% risk
Prolonged periods uninterupted ovulation
Nulliparity
1st child after 35yrs
late age menopause
white race
CLINICAL FEATURES
Present late as often ASYMPTOMATIC
LATE DIAGNOSIS COMMON
Pain
Abdominal Girth increase
bloating
ascites
Urinary retention
Mass
Constipation (bowel obstruction)
Hydronephrosis (ureteric ostruction)
SCREENING
Ca125 80% advanced ca
Not specific
PROGNOSIS 5 yr
Stage I 80-95%
Stage II 70%
Recurrence post chemo 20%
TREATMENT
Surgical
Total hysterectomy+salpingo-oophrectomy+infracolic omentectomy
Chemo
Plattinum based
Raditherapy
palliative ONLY
STAGING
I growth limited to Ovaries
II Ovarian growth with pelvic extension
III Tumour outside pelvis with +ve nodes
IV Distant organ ivolvement including pleural space & liver parenchyma
HISTOLOGY
Most adneocarcinomas
Serous
Mucoid
Endometroid
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